Anti-EOMES antibodies, mouse

Anti-EOMES antibodies, mouse

Clone: REA116 | Dilution: 1:10
Clone REA116 recognizes EOMES, also known as T-box brain protein 2 (TBr2) or eomesodermin. EOMES is a 72–74 kDa T-box transcription factor and plays a crucial role in development including trophoblast differentiation, gastrulation, brain development, and cell-mediated immunity in adults. EOMES lacking embryos are arrested at the blastocyst stage due to differentiation defects of the trophoectoderm. As a regulator of cell mediated immunity, expression of EOMES is shown to be increased in effector CD8
+
T cells, in response to infection. Further, EOMES including its paralogue T-bet are suggested to be involved in NK cell maturation.
Additional information: Clone REA116 displays negligible binding to Fc receptors.

Alternative names

TBR-2

Technical specifications

  • Antigen: EOMES
  • Clone: REA116
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TBR-2
  • Entrez Gene ID: 13813
  • Molecular mass of antigen [kDa]: 75
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Gordon, S. M. et al. (2012) The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 36(1): 55-67
    2. Pearce, E. L. et al. (2003)
      Control of effector CD8
      +
      T cell function by the transcription factor Eomesodermin.
      Science 302: 1041
    3. Kidder, B. L. et al. (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20: 458-472
Product options: 4
9 µg in 300 µL (1)
GBP 20.00
30 µg in 1 mL (1)
GBP 50.00
9 µg in 300 µL (1)
GBP 28.00
30 µg in 1 mL (1)
GBP 50.00

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