Anti-DLL4 antibodies, human

Anti-DLL4 antibodies, human

Clone: MHD4-46 | Dilution: 1:11
The human delta-like4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.

Alternative names

hdelta2

Technical specifications

  • Antigen: DLL4
  • Clone: MHD4-46
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: hdelta2
  • Entrez Gene ID: 54567
  • Molecular mass of antigen [kDa]: 72
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, Biotin
  • Selected references

    1. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32(1): 14-27
    2. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
    3. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
    4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development J. Exp. Med. 205(11): 2507-2513
    5. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(311): 2515-2523
Product options: 10
for 30
tests
(1)
GBP 60.00
for 100
tests
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GBP 150.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 70.00
for 100
tests
(1)
GBP 175.00
for 30
tests
(1)
GBP 75.00
for 100
tests
(1)
GBP 185.00
for 30
tests
(1)
GBP 80.00
for 100
tests
(1)
GBP 190.00
for 100
tests
(1)
GBP 150.00

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