Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
4Ig-B7-H3, B7-H3, B7RP-2

Specifications for CD276 Antibody, anti-human, REAfinity™


Clone REA1094 recognizes the human CD276 antigen, a type I transmembrane protein expressed at low levels in human liver, lung, bladder, testis, prostate, breast, placenta, lymphoid organs, and many human cancers. Surface expression can be induced on T cells, natural killer cells, and macrophages as well as on dendritic cells (DC) by interferon γ (IFN-γ) and on monocytes by granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). CD276 has been shown to function as costimulatory molecule for T cell activation by inducing T cell proliferation and IFN-γ production.
Additional information: Clone REA1094 displays negligible binding to Fc receptors.

Alternative names

4Ig-B7-H3, B7-H3, B7RP-2

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigen4Ig-B7-H3, B7-H3, B7RP-2
Molecular mass of antigen [kDa]54
Distribution of antigenB cells, dendritic cells, epithelial cells, macrophages, monocytes, NK cells, T cells, bladder, liver, lung, testicle, prostate, breast, placenta, tumor
Entrez Gene ID80381
RRIDAB_2733633, AB_2733796, AB_2733797, AB_2733364, AB_2733365, AB_2732972, AB_2732973, AB_2733221, AB_2733222, AB_2733108, AB_2733109, AB_2733027, AB_2733028, AB_2733514, AB_2733515, AB_2733632

Resources for CD276 Antibody, anti-human, REAfinity™


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References for CD276 Antibody, anti-human, REAfinity™


  1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3): 269-274
  2. Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U.S.A. 101(34): 12640-12645
  3. Chen, Y. W. et al. (2008) The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Curr. Cancer Drug Targets 8(5): 404-413

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