Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
NGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)

Specifications for CD271 (LNGFR) Antibody, anti-human, REAfinity™


Clone REA844 recognizes the human CD271 antigen, also known as low-affinity nerve growth factor receptor (LNGFR) or p75 neurotrophin receptor (NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 (LNGFR) was described to be expressed on cells of the central and peripheral nervous system and was suggested to be involved in the development, survival, and differentiation of cells.
Expression of CD271 (LNGFR) is found on mesenchymal stem/stromal cells (MSCs), follicular dendritic cells, mesenchymal cells involved in mesenchymal-epithelial interactions, autonomic and sensory neurons, oligodendrocytes, astrocytes, schwann cells, and neural crest stem cells.
Additional information: Clone REA844 displays negligible binding to Fc receptors.

Alternative names

NGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivitymonkey, sheep, cat, dog, pig, rabbit
AntigenCD271 (LNGFR)
Alternative names of antigenNGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)
Molecular mass of antigen [kDa]43
Distribution of antigenstem cells, dendritic cells, epithelial cells, oligodendrocytes, astrocytes, Schwann cells, mesenchymal stem cells
Entrez Gene ID4804
RRIDAB_2725868, AB_2725887, AB_2725864, AB_2725888, AB_2725865, AB_2725892, AB_2725869, AB_2725893, AB_2725870, AB_2725885, AB_2725862, AB_2725889, AB_2725866, AB_2725890, AB_2725867, AB_2725886, AB_2725863, AB_2725894, AB_2725871, AB_2725891

Resources for CD271 (LNGFR) Antibody, anti-human, REAfinity™


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References for CD271 (LNGFR) Antibody, anti-human, REAfinity™


  1. Caneva, L. et al. (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol. Dis. 21: 73-85
  2. Quirici, N. et al. (2002) Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp. Hematol. 30: 783-791
  3. Casaccia-Bonnefil, P. et al. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383: 716-719
  4. DiStefano, P. S. and Johnson, E. M. Jr. (1988) Identification of a truncated form of the nerve growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 85: 270-274
  5. Huber, L. J. and Chao, M. V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Dev. Biol. 167: 227-238
  6. Chalazonitis, A. et al. (1998)
    Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1
    in vitro
    in vivo
    Dev. Biol. 204(2): 385-406
  7. Jones, E. A. et al. (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46: 3349-3360
  8. Kashiba, H. et al. (1995) Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons. Brain Res. Mol. Brain Res. 30: 158-164
  9. Rudge, J. S. et al. (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6: 693-705
  10. Thomson, T. M. et al. (1988) Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp. Cell Res. 174: 533-539
  11. Pezzati, P. et al. (1992) Expression of nerve growth factor receptor immunoreactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490
  12. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921
  13. Vroemen, M. and Weidner, N. (2003) Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Methods 124: 135-143

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