Clone:
REAL1031
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
FLT-4, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, CD310

Specifications for VEGFR-3 (FLT-4) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1031 is an antibody fragment derived from the full VEGFR-3 (FLT-4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1031 recognizes the human VEGFR-3 (FLT-4) antigen, a Single-pass type I membrane protein known as Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4 (FLT-4) or CD310. VEGFR-3 (FLT-4) is a tyrosine-protein kinase that acts as a cell-surface receptor for the vascular endothelial growth factors VEGF-C and VEGF-D. It plays an essential role in adult lymph-angiogenesis, in the development of the vascular network and the cardiovascular system during embryonic development. During early embryogenesis all endothelial cells express VEGFR-3 (FLT-4), while in the adult tissues, VEGFR-3 (FLT-4) expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. VEGFR-3 (FLT-4) plays a major role in tumor growth and metastatic tumor cell dissemination. The receptor is over-expressed on lymphatic vessels in the vicinity of tumors and on the tumor vasculature and therefore may be an excellent target for an effective cancer intervention.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

FLT-4, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, CD310

Detailed product information

Technical specifications

CloneREAL1031
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenVEGFR-3 (FLT-4)
Alternative names of antigenFLT-4, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, CD310
Distribution of antigenendothelial cells

Resources for VEGFR-3 (FLT-4) Antibody, anti-human, REAdye_lease™

Certificates

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References for VEGFR-3 (FLT-4) Antibody, anti-human, REAdye_lease™

Publications

  1. Pajusola, K. et al. (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52(20): 5738-5743
  2. Achen, M. G. et al. (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 95(2): 548-553
  3. Tammela, T. et al. (2011) VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 13(10): 1202-1213
  4. Baker, E. et al. (2019) Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival. Breast Cancer (Auckl) 13(1178223419858957)

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