Clone:
REA910
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TCR Vb5, TCR Vbeta5

Specifications for TCR Vβ5 Antibody, anti-human, REAfinity™

Overview

Clone REA910 recognizes the human variable β 5 subunit of the αβ T cell receptor (TCR Vβ5). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ5 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell–mediated immunity and underpins MHC restriction.
Additional information: Clone REA910 displays negligible binding to Fc receptors.

Alternative names

TCR Vb5, TCR Vbeta5

Detailed product information

Technical specifications

CloneREA910
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivitypigtailed macaque
AntigenTCR Vβ5
Alternative names of antigenTCR Vb5, TCR Vbeta5
Molecular mass of antigen [kDa]10
Distribution of antigenT cells
Entrez Gene ID28614, 28613
RRIDAB_2726909, AB_2726875, AB_2726910, AB_2726876, AB_2726911, AB_2726877, AB_2726912, AB_2726878, AB_2801686, AB_2801685, AB_2726908, AB_2726874, AB_2811441, AB_2811435

Resources for TCR Vβ5 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TCR Vβ5 Antibody, anti-human, REAfinity™

Publications

  1. Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40(1): 27-36
  2. Killestein, J. et al. (2002)
    Antibody-mediated suppression of Vbeta5.2/5.3
    +
    T cells in multiple sclerosis: results from an MRI-monitored phase II clinical trial.
    Ann. Neurol. 51(4): 467-474
  3. Joedicke, J. J. et al. (2014)
    Activated CD8
    +
    T cells induce expansion of Vβ5
    +
    regulatory T cells via TNFR2 signaling.
    J. Immunol. 193(6): 2952-2960

Related products for
TCR Vβ5 Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?