Clone:
REA917
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
Calgranulin A, Calprotectin, S100A8, CAGA, CFAG, MRP8

Specifications for S100A8 Antibody, anti-human, REAfinity™

Overview

Clone REA917 recognizes the calcium- and zinc-binding protein S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8), calprotectin, or calgranulin-A. S100A8 is mainly expressed in myeloid cells, e.g., monocytes, macrophages, and granulocytes and upregulated in different tumors, e.g., in skin, breast, colon, pancreatic, bladder, and ovarian malignancies. S100A8 is involved in the regulation of inflammatory processes and immune response and plays a role in antimicrobial, cytostatic, and chemotactic activities.
Additional information: Clone REA917 displays negligible binding to Fc receptors.

Alternative names

Calgranulin A, Calprotectin, S100A8, CAGA, CFAG, MRP8

Detailed product information

Technical specifications

CloneREA917
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenS100A8
Alternative names of antigenCalgranulin A, Calprotectin, S100A8, CAGA, CFAG, MRP8
Molecular mass of antigen [kDa]11
Distribution of antigenepithelial cells, granulocytes, macrophages, monocytes, tumor cells, neutrophils
Entrez Gene ID6279
RRIDAB_2726963, AB_2727021, AB_2726964, AB_2727022, AB_2726965, AB_2727020

Resources for S100A8 Antibody, anti-human, REAfinity™

Certificates

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References for S100A8 Antibody, anti-human, REAfinity™

Publications

  1. Rammes, A. et al. (1997) Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 272(14): 9496-9502
  2. Viemann, D. et al. (2005) Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 105(7): 2955-2962
  3. Ehrchen, J. M. et al. (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J. Leukoc. Biol. 86(3): 557-566

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