Clone:
REA723
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
mRNA export factor, Rae1, Mrnp41

Specifications for Rae-1 Pan Specific Antibody, anti-mouse, REAfinity™

Overview

Clone REA723 recognizes the Rae-1 pan specific antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1 was detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumor cells induce potent priming of cytotoxic T cells and sensitization of NK cells
in vivo
. Clone REA723 detects Rae-1α/β/γ/δ/ε.
Additional information: Clone REA723 displays negligible binding to Fc receptors.

Alternative names

mRNA export factor, Rae1, Mrnp41

Detailed product information

Technical specifications

CloneREA723
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenRae-1 Pan Specific
Alternative names of antigenmRNA export factor, Rae1, Mrnp41
Molecular mass of antigen [kDa]41
Distribution of antigenT cells, NK cells
Entrez Gene ID66679
RRIDAB_2653323, AB_2653324, AB_2653325, AB_2653326, AB_2653327, AB_2653328, AB_2653329, AB_2653330, AB_2653322, AB_2653320

Resources for Rae-1 Pan Specific Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Rae-1 Pan Specific Antibody, anti-mouse, REAfinity™

Publications

  1. Nomura, M. et al. (1996) Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biol. Chem. 120(5): 987-995
  2. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
  3. Diefenbach, A. et al. (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413(6852): 165-171

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