Clone:
REA719
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Paired box protein Pax-3, HuP2, Pax3

Extended validation for PAX-3 Antibody, anti-human/mouse, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA719
274212++
Cells were incubated with an excess of purified unconjugated PAX-3 (REA719) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for PAX-3 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA719 recognizes the human and mouse paired box protein PAX-3 antigen, a member of the paired box (PAX) gene family whose protein products are transcription factors involved in development. PAX-3 regulates cell proliferation, migration, and apoptosis and plays a role in neural development and myogenesis. Human and mouse PAX-3 share 98% amino acid sequence identity.
Additional information: Clone REA719 displays negligible binding to Fc receptors.

Alternative names

Paired box protein Pax-3, HuP2, Pax3

Detailed product information

Technical specifications

CloneREA719
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenPAX-3
Alternative names of antigenPaired box protein Pax-3, HuP2, Pax3
Molecular mass of antigen [kDa]53(same molecular weight for human and mouse/rat)
Entrez Gene ID5077, 18505
RRIDAB_2653155, AB_2653156, AB_2653157, AB_2653154

Resources for PAX-3 Antibody, anti-human/mouse, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for PAX-3 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Tassabehji, M. et al. (1992) Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 355(6361): 635-636
  2. Begum, S. et al. (2005) Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR. Oncogene 24(11): 1860-1872
  3. Wang, Q. et al. (2006)
    Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes
    in vitro
    .
    Cancer Res. 66(17): 8574-8580

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