Clone:
20d5
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
KLRC1, CD159a, NKG2A, NKG2B, NKG2C1, KLRC2, NKG2E, KLRC3, CD159c

Specifications for NKG2A/C/E Antibody, anti-mouse

Overview

Clone 20d5 recognizes the mouse NKG2A, NKG2C and NKG2E antigen on a subset of NK and NK-T cells in most mouse strains (e.g. AKR/J, BALB/c, C3H/He,C57BL/6, CBA/J, DBA/1, FVB/N, 129/Sv, NOD, SWR, and most DBA/2 substrains, but not DBA/2J). The C-type lectin-like NKG2 receptors form heterodimers of CD94 and one of several NKG2 family members, i.e., NKG2A (CD159a), NKG2C (CD159c), or NKG2E. CD94/NKG2 receptors monitor classical class I expression indirectly by means of the recognition of classical class I signal peptides. These signal peptides are processed to a nonamer peptide called Qdm that is presented to CD94/NKG2
+
NK cells by a nonclassical MHC class I molecule called Qa-1. CD94/NKG2 receptors equip NK cells with the capacity to detect cells with abnormal MHC class I expression, such as often results from viral infection or transformation.

Alternative names

KLRC1, CD159a, NKG2A, NKG2B, NKG2C1, KLRC2, NKG2E, KLRC3, CD159c

Detailed product information

Technical specifications

Clone20d5
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenNKG2A/C/E
Alternative names of antigenKLRC1, CD159a, NKG2A, NKG2B, NKG2C1, KLRC2, NKG2E, KLRC3, CD159c
Molecular mass of antigen [kDa]28
Distribution of antigenNK cells
Entrez Gene ID16641
RRIDAB_2653003, AB_2653004, AB_2653005, AB_2653006, AB_2653007, AB_2653008, AB_2653009, AB_2653010, AB_2653011, AB_2653012, AB_2653013, AB_2653014, AB_2653015, AB_2653016, AB_2653017, AB_2653018

Resources for NKG2A/C/E Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for NKG2A/C/E Antibody, anti-mouse

Publications

  1. Foley, B. et al. (2012)
    Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C
    +
    natural killer cells with potent function.
    Blood 119(11): 2665-2674
  2. Lohwasser, S. et al. (1999) Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur. J. Immunol. 29(3): 755-761
  3. Silver, E. T. et al. (1999) Molecular cloning of mouse NKG2A and C. Immunogenetics 49(7-8): 727-730

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