CD314 (NKG2D) antibodies, mouse

CD314 (NKG2D) antibodies, mouse

Clone: REA1175 | Dilution: 1:50
Clone REA1175 recognizes the mouse CD314 (NKG2D), a type II transmembrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family. CD314 in mice is expressed on activated CD8
αβ T cells, NK cells, subsets of γδ T cells, IFN-producing killer dendritic cells, subsets of NKT cells, and activated macrophages. For signaling, CD314 associates with signaling adapters DAP10 and DAP12 and transduces signal via the PI3-kinase pathway and the Syk-Zap70 pathways, respectively. CD314 recognizes multiple ligands, which are either uregulated in response to cellular stresses such as heat shock, infection, and DNA damage or are constitutively expressed, such as on tumor cells. Known ligands of CD314 in mice include murine UL16-binding protein-like transcript (MULTI), H60 family proteins and the five retinoic acid-inducible proteins RAE-1α, β, γ, δ, ε. Interaction of CD314 with its ligands regulates cytotoxic response towards the cells bearing the cognate ligands.
Additional information: Clone REA1175 displays negligible binding to Fc receptors.

Alternative names

Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Technical specifications

  • Antigen: CD314 (NKG2D)
  • Clone: REA1175
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d
  • Entrez Gene ID: 27007
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: T cells, NK cells, macrophages, dendritic cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, Biotin, PE
  • Selected references

    1. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
    2. McMahon, C. et al. (2002) The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17(1): 19-29
    3. Yokoyama, W. M. et al. (2002) NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3(12): 1150-1155
    4. Takada, A. et al. (2008) Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol. 180: 1678-1685
Product options: 5
30 µg in 200 µL (1)
EUR 67,00 
30 µg in 200 µL (1)
EUR 82,00 
30 µg in 200 µL (1)
EUR 103,00 
150 µg in 1 mL (1)
EUR 288,00 
30 µg in 200 µL (1)
EUR 41,00 

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