Anti-JAML antibodies, mouse

Anti-JAML antibodies, mouse

Clone: REA862 | Dilution: 1:50
Clone REA862 recognizes the mouse JAML antigen, also known as AMICA1 or junctional adhesion molecule-like protein. JAML is a transmembrane protein, which consists of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. JAML is found on γ/δ intraepithelial T cells. The costimulatory molecule JAML binds to its ligands Coxsackie virus and adenovirus receptor (CAR), that leads to cellular proliferation and cytokine and growth factor production.
Additional information: Clone REA862 displays negligible binding to Fc receptors.

Alternative names

AMICA1, junctional adhesion molecule-like

Technical specifications

  • Antigen: JAML
  • Clone: REA862
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: AMICA1, junctional adhesion molecule-like
  • Entrez Gene ID: 270152
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Zen, K. et al. (2005) Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol. Biol. Cell 16(6): 2694-2703
    2. Witherden, D. A. et al. (2010) The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 329(5996): 1205-1210
Product options: 6
30 µg in 200 µL (1)
EUR 67,00 
150 µg in 1 mL (1)
EUR 196,00 
30 µg in 200 µL (1)
EUR 82,00 
150 µg in 1 mL (1)
EUR 232,00 
30 µg in 200 µL (1)
EUR 41,00 
150 µg in 1 mL (1)
EUR 118,00 

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