Anti-CCR10 antibodies, human

Anti-CCR10 antibodies, human

Clone: REA326 | Dilution: 1:50
Clone REA326 recognizes the human C-C chemokine receptor type 10 (CCR10) antigen, a multi-pass membrane protein which is also known as G-protein–coupled receptor 2 (GPR2). CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus. Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response. On the other hand, IgA antibody–producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites. CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity. CCL27 is up-regulated in inflamed skin, whereas CCL28 is selectively expressed in intestinal epithelium.
In vitro
, CCL27−CCR10 interactions mediate the preferential migration of skin-homing CLA-bearing memory T cells. Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or -originated cancer cells for their survival, proliferation, and evasion from immune surveillance.
Additional information: Clone REA326 displays negligible binding to Fc receptors.

Alternative names

GPR2, G-protein coupled receptor 2 (GPR2, GPR-2)

Technical specifications

  • Antigen: CCR10
  • Clone: REA326
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GPR2, G-protein coupled receptor 2 (GPR2, GPR-2)
  • Entrez Gene ID: 2826
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Jarmin, D. I. et al. (2000) Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J. Immunol. 164(7): 3460-3464
    2. Sisirak, V. et al. (2011) CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues. Blood 118(19): 5130-5140
    3. Brugman, S. et al. (2018) BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells. Eur. J. Immunol. 48(24): 283-292
    4. Homey, B. et al. (2002) CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat. Med. 8(2): 157-165
    5. Fenton, K. A. et al. (2018) Mesenchymal stem cells and T cells in the formation of tertiary lymphoid structures in lupus nephritis. Sci. Rep. 8(1): 7861
    6. Xiong, N. et al. (2012) CCR10 and its ligands in regulation of epithelial immunity and diseases. Protein Cell 3(8): 571-580
Product options: 4
for 30
EUR 93,00 
for 100
EUR 227,00 
for 30
EUR 108,00 
for 100
EUR 268,00 

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