Anti-CCL2 (MCP-1) antibodies, human, mouse, rat

Anti-CCL2 (MCP-1) antibodies, human, mouse, rat

Clone: REA485 | Dilution: 1:10
Clone REA483 recognizes the human, mouse, and rat C-C motif chemokine 2 (CCL2) antigen, which is also known as monocyte chemotactic protein 1 (MCP-1) or platelet-derived growth factor-inducible protein JE. CCL2 is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. Human CCL2 is composed of 76 amino acids and is 13 kDa in size. CCL2 is produced either constitutively or after induction by oxidative stress, cytokines, or growth factors. It is produced by many cell types, including endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells. These cells are important for antiviral immune responses in the peripheral circulation and in tissues. However, monocyte/macrophages are found to be the major source of CCL2. It regulates the migration and infiltration of monocytes, memory T lymphocytes, and natural killer (NK) cells. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis, or atherosclerosis.
Additional information: Clone REA483 displays negligible binding to Fc receptors.

Alternative names

GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je

Technical specifications

  • Antigen: CCL2 (MCP-1)
  • Clone: REA485
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je
  • Entrez Gene ID: 6347, 20296, 24770
  • Molecular mass of antigen [kDa]: 9, 14
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: endothelial cells, macrophages, monocytes, epithelial cells, astrocytes, microglia, fibroblasts, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Kawahara, R. S. et al. (1989) Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4. J. Biol. Chem. 264(2): 679-682
    2. Yoshimura, T. and Leonard, E. J. (1991) Human monocyte chemoattractant protein-1 (MCP-1). Adv. Exp. Med. Biol. 305: 47-56
    3. Deshmane, S. L. et al. (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 29(6): 313-326
Product options: 4
for 30
EUR 93,00 
for 100
EUR 227,00 
for 30
EUR 108,00 
for 100
EUR 268,00 

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