Clone:
REA721
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Interleukin-22, IL-TIF

Specifications for IL-22 Antibody, anti-mouse, REAfinity™

Overview

Clone REA721 recognizes the mouse interleukin 22 (IL-22) antigen, also known as IL-TIF. IL-22 is α-helical cytokine which is a member of the IL-10 cytokine family. It is produced by immune cells, including activated dendritic cells, T cells, and NK cells. The biological activity of IL-22 is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains. It initiates immune responses against bacterial pathogens especially in epithelial cells.
Additional information: Clone REA721 displays negligible binding to Fc receptors.

Alternative names

Interleukin-22, IL-TIF

Detailed product information

Technical specifications

CloneREA721
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-22
Alternative names of antigenInterleukin-22, IL-TIF
Molecular mass of antigen [kDa]17
Distribution of antigendendritic cells, NK cells, T cells
Entrez Gene ID50929
RRIDAB_2652435, AB_2652434

Resources for IL-22 Antibody, anti-mouse, REAfinity™

Certificates

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References for IL-22 Antibody, anti-mouse, REAfinity™

Publications

  1. Domoutier, L. et al. (2000) Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. 164(4): 1814-1819
  2. Dumoutier, L. et al. (2000) IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun. 1(8): 488-494
  3. Wolk, K. et al. (2004) IL-22 increases the innate immunity of tissues. Immunity 21(2): 241-254
  4. Jones, B.C. et al. (2008) Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure 16(9): 1333-1344

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