Clone:
24D2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, p185erbB2

Specifications for ErbB-2 (CD340) Antibody, anti-human

Overview

Clone 24D2 recognizes the human receptor tyrosine-protein kinase ErbB-2 antigen, a single-pass type I membrane protein which is also known as CD340, human epidermal growth factor receptor 2 (Her2), or proto-oncogene Neu. ErbB-2 is a member of the epidermal growth factor receptor family. The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. ErbB-2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. ErbB-2 has been shown to be involved in embryonic development and cancer progression. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of cancer. In recent years the protein has become an important biomarker.

Alternative names

ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, p185erbB2

Detailed product information

Technical specifications

Clone24D2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenErbB-2 (CD340)
Alternative names of antigenERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, p185erbB2
Molecular mass of antigen [kDa]136(refers to canonical form)
Distribution of antigenother
Entrez Gene ID2064
RRIDAB_2857550, AB_2857767, AB_2857755, AB_2857833, AB_2857830, AB_2651644, AB_2651645, AB_2651650, AB_2651651, AB_2857556

Resources for ErbB-2 (CD340) Antibody, anti-human

Certificates

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References for ErbB-2 (CD340) Antibody, anti-human

Publications

  1. Yamamoto, T. et al. (1986) Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 319(6050): 230-234
  2. Wang, Y. N. et al. (2012) Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J. Biol. Chem. 287(20): 16869-16879
  3. Tsutsui, S. et al. (2002) Prognostic value of c-erbB2 expression in breast cancer. J Surg Oncol 79(4): 216-223

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