Clone:
REA882
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CRTAM

Specifications for CD355 (CRTAM) Antibody, anti-mouse, REAfinity™

Overview

Clone REA882 recognizes the mouse CD355 antigen, also known as class I MHC-restricted T cell associated molecule (CRTAM). CD355 is a type I immunoglobulin-superfamily transmembrane receptor, which is expressed by activated CD8
+
T cells and NK cells, but it is also found on spleen, brain, and testis. CD355 recognizes nectin-like molecule 2 (Necl-2), a cell-surface protein that mediates epithelial cell junctions and interactions with other nectins and Necls. In association with Necl-2, CD355 promotes cytotoxicity of NK cells and IFN-γ secretion of CD8
+
T cells and NK cell–mediated rejection of tumors.
Additional information: Clone REA882 displays negligible binding to Fc receptors.

Alternative names

CRTAM

Detailed product information

Technical specifications

CloneREA882
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD355 (CRTAM)
Alternative names of antigenCRTAM
Molecular mass of antigen [kDa]42
Distribution of antigenT cells, NK cells
Entrez Gene ID54698
RRIDAB_2726629, AB_2726714, AB_2726630, AB_2726715, AB_2726631, AB_2726716, AB_2726632, AB_2726717, AB_2726712, AB_2726628, AB_2726713

Resources for CD355 (CRTAM) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD355 (CRTAM) Antibody, anti-mouse, REAfinity™

Publications

  1. Kennedy, J. et al. (2000) A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J. Leukoc. Biol. 67(5): 725-734
  2. Boles, K. S. et al. (2005)
    The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8
    +
    T-cell responses through the cell-surface receptor CRTAM.
    Blood 106: 779-786
  3. Yeh, J. H. et al. (2008) Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell 132(5): 846-859

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