Clone:
REAL846
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2

Specifications for CD270 (HVEM) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL846 is an antibody fragment derived from the full CD270 (HVEM) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL846 recognizes CD270, which is also known as HVEM or TNFRSF14 (Tumor necrosis factor receptor superfamily member 14). CD270 derives its name based on the ability of types 1 and 2 herpesvirus gD to bind to it for entry into the cell. CD270 is a type 1 transmembrane protein with a predicted molecular weight of 30 kDa and is a member of TNFR superfamily. CD270 transmits both activating and inhibitory signals for, e.g., interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. Expression of CD270 is widely distributed and is found on hematopoietic cells such as dendritic cells, Tregs, monocytes, neutrophils, NK cells, B cells, and T cells, as well as on non-hematopoietic cells. Lymphomas, malignant melanomas and cases of prostate, colorectal, renal and urothelial cancers displayed moderate to strong cytoplasmic staining.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2

Detailed product information

Technical specifications

CloneREAL846
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD270 (HVEM)
Alternative names of antigenTNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2
Distribution of antigenT cells, B cells, dendritic cells, monocytes, NK cells, neutrophils, other, stomach

Resources for CD270 (HVEM) Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD270 (HVEM) Antibody, anti-human, REAdye_lease™

Publications

  1. Ware, C. F. et al. (2009) Targeting the LIGHT-HVEM pathway. Adv. Exp. Med. Biol. 647: 146-155
  2. Pasero, C. et al. (2012) The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr. Opin. Pharmacol. 12(4): 478-485

Related products for
CD270 (HVEM) Antibody, anti-human, REAdye_lease™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?