Clone:
REA1227
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klrk1, NKG2-D

Specifications for CD267 (TACI) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1227 recognizes the mouse CD267 antigen, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ), and B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI
/
mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation.
Additional information: Clone REA1227 displays negligible binding to Fc receptors.

Alternative names

Klrk1, NKG2-D

Detailed product information

Technical specifications

CloneREA1227
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD267 (TACI)
Alternative names of antigenKlrk1, NKG2-D
Molecular mass of antigen [kDa]27
Distribution of antigenT cells, B cells
Entrez Gene ID27007
RRIDAB_2811601, AB_2811602, AB_2811603, AB_2811600

Resources for CD267 (TACI) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD267 (TACI) Antibody, anti-mouse, REAfinity™

Publications

  1. Yan, X. et al. (2003) A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood 102: 184-191
  2. Batten, M. et al. (2004) TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J. Immunol. 172: 812-822
  3. Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19(3–4): 263-276

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