Clone:
8F10
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
Klrk1, NKG2-D

Specifications for CD267 (TACI) Antibody, anti-mouse

Overview

Clone 8F10 recognizes CD267, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ) and, B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI
-/-
mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T-cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation.

Alternative names

Klrk1, NKG2-D

Detailed product information

Technical specifications

Clone8F10
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD267 (TACI)
Alternative names of antigenKlrk1, NKG2-D
Molecular mass of antigen [kDa]27
Distribution of antigenB cells, T cells
Entrez Gene ID27007
RRIDAB_2656775, AB_2656776, AB_2656777, AB_2656778, AB_2656779, AB_2656774

Resources for CD267 (TACI) Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD267 (TACI) Antibody, anti-mouse

Publications

  1. Batten, M. et al. (2004) TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J. Immunol. 172: 812-822
  2. Yan, M. et al. (2001) Activation and accumulation of B cells in TACI-deficient mice. Nat. Immunol. 2(7): 638-643
  3. Mackay, F. et al. (2008) TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 19(3–4): 263-276

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