Clone:
REA425
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ALK, NBLST3

Specifications for CD246 (ALK) Antibody, anti-human, REAfinity™

Overview

Clone REA425 recognizes both the normal human CD246 and the nucleolar protein nucleophosmin-CD246 (NPM-CD246) chimeric antigen. CD246 is a single-pass type I membrane protein which is also known as anaplastic lymphoma kinase (ALK). It is a neuronal orphan receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-CD246 gene. CD246 plays an important role in the genesis and differentiation of the nervous system. It is essentially and transiently expressed in specific regions of the central and peripheral nervous systems. CD246 is also expressed in the small intestine and testis, but not in normal lymphoid cells. It transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase pathway. Anaplastic large cell lymphoma (ALCL) is a heterogeneous group of diseases by morphology, phenotype, genotype, and clinical presentation. The production of the fusion product NPM-CD246, which is associated with ALCL, is a result of the t(2;5)(p23;q35) chromosomal translocation.
Additional information: Clone REA425 displays negligible binding to Fc receptors.

Alternative names

ALK, NBLST3

Detailed product information

Technical specifications

CloneREA425
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD246 (ALK)
Alternative names of antigenALK, NBLST3
Molecular mass of antigen [kDa]175
Distribution of antigenother, small intestine, testicle
Entrez Gene ID238
RRIDAB_2656638, AB_2656639, AB_2656640, AB_2656641, AB_2656642, AB_2656643, AB_2656644, AB_2656645

Resources for CD246 (ALK) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD246 (ALK) Antibody, anti-human, REAfinity™

Publications

  1. Morris, S. W. et al. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263(5151): 1281-1284
  2. Tennstedt, P. et al. (2014) Patterns of ALK expression in different human cancer types. J. Clin. Pathol. 67(6): 477-481
  3. Iwahara, T. et al. (1997) Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14(4): 439-449

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