Clone:
MB22-9F5
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
CLEC4K, Langerin

Specifications for CD207 (Langerin) Antibody, anti-human

Overview

Langerin (CD207 antigen), a 40 kDa, glycosylated type II transmembrane C-type lectin receptor, is the standard marker for human and murine Langerhans cells (LCs).
LCs are a subset of dendritic cells (DCs) cells that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis.
CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs.

Alternative names

CLEC4K, Langerin

Detailed product information

Technical specifications

CloneMB22-9F5
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD207 (Langerin)
Alternative names of antigenCLEC4K, Langerin
Molecular mass of antigen [kDa]37
Distribution of antigendendritic cells, Langerhans cells
Entrez Gene ID50489
RRIDAB_2656227, AB_2656228, AB_2656229, AB_2656230, AB_2656231, AB_2656232, AB_2656233, AB_2656234, AB_2656235, AB_2656226

Resources for CD207 (Langerin) Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD207 (Langerin) Antibody, anti-human

Publications

  1. Valladeau, J. et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12(1): 71-81
  2. Geissmann, F. et al. (1998) Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells J. Exp. Med. 187(6): 961-996
  3. Rozis, G. et al. (2008) Human Langerhans cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands Immunology 124(3): 329-338
  4. Romani, N. et al. (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 234(1): 120-141
  5. Stoitzner, P. et al. (2010) Isolation of skin dendritic cells from mouse and man. Methods Mol. Biol. 595: 235-248

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