Clone:
OX-104
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
MOX1, Mox2, MRC, OX2, MOX1/2

Specifications for CD200 Antibody, anti-human

Overview

Clone OX-104 reacts with the human CD200 antigen, also known as MRC, MOX1/2, and OX-2, a type-1 membrane glycoprotein, which contains two immunoglobulin domains. Studies of the related gene in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. CD200 may serve as a cancer stem cell marker as co-expression with other reported stem cell markers was found on prostate, breast, brain, and colon cancers. In addition, CD200 expression was shown to be a prognostic factor in AML and multiple myeloma.

Alternative names

MOX1, Mox2, MRC, OX2, MOX1/2

Detailed product information

Technical specifications

CloneOX-104
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD200
Alternative names of antigenMOX1, Mox2, MRC, OX2, MOX1/2
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, dendritic cells, endothelial cells, T cells, neurons, mesenchymal stem cells, ES and iPS cells, smooth muscle
Entrez Gene ID4345
RRIDAB_2857676, AB_2656107, AB_2656108, AB_2656111, AB_2857688

Resources for CD200 Antibody, anti-human

Documents and Protocols

Certificates

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References for CD200 Antibody, anti-human

Publications

  1. Moreaux, J. et al. (2007) CD200 as a prognostic factor in acute myeloid leukemia. Blood 108: 4194-4197
  2. Kawasaki, B. T. et al. (2007) Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochem. Biophys. Res. Commun. 364: 778-782
  3. Tonks, A. et al. (20007) CD200 as a prognostic factor in acute myeloid leukemia. Leukemia 21: 566-568
  4. Minas, K. et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit. Rev. Immunol. 26: 213-230

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