Clone:
REA620
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL-6R 1, IL-6R-alpha, IL-6RA, IL-6R, Il6r

Specifications for CD126 (IL-6Rα) Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA620 recognizes the mouse CD126 antigen, a type I cytokine receptor, also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. It associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor complex. IL-6 plays essential roles in immune response, acute phase reaction, and hematopoiesis. It is an essential factor for B cell differentiation to antibody-forming cells. Deregulated expression of the IL-6 gene is involved in polyclonal plasma cell abnormalities and oncogenesis of plasma cell neoplasias. IL-6 functions as a potent growth factor for multiple myelomas as well as plasmacytomas.
Additional information: Clone REA620 displays negligible binding to Fc receptors.

Alternative names

IL-6R 1, IL-6R-alpha, IL-6RA, IL-6R, Il6r

Detailed product information

Technical specifications

CloneREA620
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Speciesmouse, rat
AntigenCD126 (IL-6Rα)
Alternative names of antigenIL-6R 1, IL-6R-alpha, IL-6RA, IL-6R, Il6r
Molecular mass of antigen [kDa]49
Distribution of antigenB cells, monocytes, T cells, plasma cells
Entrez Gene ID16194
RRIDAB_2654816, AB_2654817, AB_2654818, AB_2654819, AB_2654820, AB_2654821, AB_2654822, AB_2654815

Resources for CD126 (IL-6Rα) Antibody, anti-mouse/rat, REAfinity™

Certificates

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References for CD126 (IL-6Rα) Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Yadav, M. et al. (2008) Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine Profile. J. Immunol. 180(5): 2772-2776
  2. Walker, F. et al. (2008) IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 111(8): 3978-3985
  3. Sugita, T. et al. (1990) Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J. Exp. Med. 171(6): 2001-2009

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