Clone:
REA443
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CO-029, TM4SF3, Tspan-8, D6.1A

Specifications for TSPAN8 Antibody, anti-human, REAfinity™

Overview

Clone REA443 recognizes the human tetraspanin-8 (TSPAN8) antigen, a multi-pass membrane protein which is also known as transmembrane 4 superfamily member 3 (TM4SF3) or tumor-associated antigen CO-029. TSPAN8 is a member of the transmembrane 4 superfamily, which is a group of cell surface glycoproteins that contain four transmembrane domains and two conserved extracellular loops. Tetraspanins interact and form complexes with a wide variety of proteins, including other members of the tetraspanin family, integrins, receptors, and signaling molecules. Through these interactions, they play important roles in fundamental cellular processes such as migration, proliferation, and differentiation. It is suggested that TSPAN8 is widely expressed in various tissues, including in the digestive tract, connective tissue, bone, muscle, and kidney. TSPAN8 has also been intensively studied in the field of cancer. It has been shown to be highly expressed in colorectal, hepatocellular, and pancreatic carcinoma cells along with integrin family proteins. Several studies have suggested that TSPAN8 is also involved in the migration and invasion of cancer cells.
Additional information: Clone REA443 displays negligible binding to Fc receptors.

Alternative names

CO-029, TM4SF3, Tspan-8, D6.1A

Detailed product information

Technical specifications

CloneREA443
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTSPAN8
Alternative names of antigenCO-029, TM4SF3, Tspan-8, D6.1A
Molecular mass of antigen [kDa]26
Distribution of antigencolorectal carcinoma cells, hepatocellular carcinoma cells, pancreatic carcinoma cells, bone, kidney, muscle
Entrez Gene ID7103
RRIDAB_2733909, AB_2654246, AB_2654247, AB_2654250, AB_2654251, AB_2654252, AB_2654253, AB_2654254, AB_2654255, AB_2733908

Resources for TSPAN8 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TSPAN8 Antibody, anti-human, REAfinity™

Publications

  1. Szala, S. et al. (1990) Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proc. Natl. Acad. Sci. U.S.A. 87(17): 6833-6837
  2. Nazarenko, I. et al. (2010) Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 70(4): 1668-1678
  3. Hirukawa, T. et al. (2014) Kidney diseases enhance expression of tetraspanin-8: a possible protective effect against tubular injury. Nephron Extra 4(1): 70-81

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