Clone:
REA916
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TACSTD2, GA733-1, M1S1, TROP2, EGP-1

Specifications for TROP2 Antibody, anti-human, REAfinity™

Overview

Clone REA916 recognizes the human TROP2 antigen, a type I membrane glycoprotein also known as tumor-associated calcium signal transducer 2 (TACSTD2). TROP2 acts as a signal transducer and may be involved in regulating the growth of carcinoma cells. It is strongly expressed by a variety of human carcinomas, but also on trophoblasts and epithelial cells.
Additional information: Clone REA916 displays negligible binding to Fc receptors.

Alternative names

TACSTD2, GA733-1, M1S1, TROP2, EGP-1

Detailed product information

Technical specifications

CloneREA916
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTROP2
Alternative names of antigenTACSTD2, GA733-1, M1S1, TROP2, EGP-1
Molecular mass of antigen [kDa]33
Distribution of antigenepithelial cells, other, placenta
Entrez Gene ID4070
RRIDAB_2726956, AB_2726914, AB_2726880, AB_2726915, AB_2726881, AB_2726913, AB_2726879, AB_2727013

Resources for TROP2 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TROP2 Antibody, anti-human, REAfinity™

Publications

  1. Fornaro, M. et al. (1995) Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer 62(5): 610-618
  2. Ripani, E. et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int. J. Cancer 76(5): 671-676
  3. Cubas, R. et al. (2010) Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol. Cancer 9(253)

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