Clone:
REA692
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HAVcr-1, TIMD-1, KIM-1, TIM, TIM1

Specifications for TIM-1 Antibody, anti-mouse, REAfinity™

Overview

Clone REA692 recognizes the mouse T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein, also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity
in vivo
through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naive CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Tʜ1/Tʜ17 cytokine production. It is reported, that the interaction of TIM-1 with TIM-4 is involved in the regulation of T cell proliferation.
Additional information: Clone REA692 displays negligible binding to Fc receptors.

Alternative names

HAVcr-1, TIMD-1, KIM-1, TIM, TIM1

Detailed product information

Technical specifications

CloneREA692
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTIM-1
Alternative names of antigenHAVcr-1, TIMD-1, KIM-1, TIM, TIM1
Molecular mass of antigen [kDa]31
Distribution of antigenT cells, kidney
Entrez Gene ID171283
RRIDAB_2654154, AB_2654155, AB_2654156, AB_2654157, AB_2654158, AB_2654159, AB_2654160, AB_2654161, AB_2654162, AB_2654153

Resources for TIM-1 Antibody, anti-mouse, REAfinity™

Certificates

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References for TIM-1 Antibody, anti-mouse, REAfinity™

Publications

  1. Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40(4): 542-553
  2. Meyers, J. H. et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat. Immunol. 6(5): 455-464
  3. Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72(8): 6621-6628
  4. Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87(15): 8327-8341

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