Clone:
REA1202
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
VSIG9, Vstm3, WUCAM

Specifications for TIGIT Antibody, anti-human, REAfinity™

Overview

Clone REA1202 recognizes the human TIGIT antigen (T cell immunoglobulin and ITIM domain). It is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation.
Additional information: Clone REA1202 displays negligible binding to Fc receptors.

Alternative names

VSIG9, Vstm3, WUCAM

Detailed product information

Technical specifications

CloneREA1202
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTIGIT
Alternative names of antigenVSIG9, Vstm3, WUCAM
Molecular mass of antigen [kDa]24
Distribution of antigenT cells, NK cells
Entrez Gene ID201633
RRIDAB_2876989, AB_2876924, AB_2876925, AB_2877005, AB_2877006, AB_2876988

Resources for TIGIT Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TIGIT Antibody, anti-human, REAfinity™

Publications

  1. Yu, X. et al. (2008) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10: 48-57
  2. Levin, S. D. et al. (2011) Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur. J. Immunol. 41(4): 902-915

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