Clone:
REA657
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TCR Vb11, TCR Vbeta11

Specifications for TCR Vβ11 Antibody, anti-mouse, REAfinity™

Overview

Clone REA657 recognizes the mouse V beta 11 T cell receptor (TCR Vβ11). The T cell receptor (TCR) is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. T cells expressing this receptor are referred to as TCRα/β T cells, though a minority of T cells express an alternate receptor, formed by variable gamma and delta chains, referred as TCRγ/δ T cells. TCR Vβ11 is a variant of the TCR β chain and is expressed on mouse strains with the b haplotype in the TCR β gene complex, including C57BL/6 and B10, but not on mice strains with the a haplotype, including C57L, SJL, and SWR.
Additional information: Clone REA657 displays negligible binding to Fc receptors.

Alternative names

TCR Vb11, TCR Vbeta11

Detailed product information

Technical specifications

CloneREA657
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vβ11
Alternative names of antigenTCR Vb11, TCR Vbeta11
Distribution of antigenT cells
Entrez Gene ID100124671
RRIDAB_2653748, AB_2653749, AB_2653750, AB_2653751, AB_2653752, AB_2653753, AB_2653754, AB_2653755, AB_2653756, AB_2653757, AB_2653758, AB_2653759, AB_2653760, AB_2653761, AB_2653762, AB_2653763

Resources for TCR Vβ11 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for TCR Vβ11 Antibody, anti-mouse, REAfinity™

Publications

  1. Bill, J. et al. (1989) The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells. J. Exp. Med. 169(4): 1405-1419
  2. Davis, M. M. et al. (1998) Ligand recognition by alpha beta T cell receptors. Annu. Rev. Immunol. 16: 523-544
  3. DiRienzo, C. G. et al. (2007)
    T-cell receptor V(alpha) usage by effector CD4
    +
    Vbeta11
    +
    T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.
    Biol. Blood Marrow Transplant. 13(3): 265-276

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