IL-2 stands for interleukin 2. Rat IL-2 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Rat IL-2

Overview

IL-2 stands for interleukin 2. Rat IL-2 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Rat IL-2 can be used for a variety of applications, including:
  • In vitro activation and propagation of T cells.
  • In vitro activation and expansion of NK cells.
  • Generation of lymphokine-activated killer (LAK) cells.

Detailed product information

Background information

Interleukin 2 (IL-2), a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. IL-2 is produced by activated T cells, especially the CD4
+
T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells, and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- and common γ-chain. The latter two are also involved in IL-15 signaling.

Biological activity

  • Stimulation of murine CTLL-2 cells
  • research grade: ≥ 2.5×
    10
    6
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Rat IL-2

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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