Clone:
REAL589
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Phosphatidylinositol 3-kinase, PI3-kinase, anti-PI3K p85 alpha, PIK3R1, GRB1

Specifications for PI3K p85 α Antibody, anti-human, REAdye_lease™

Overview

Clone REAL589 is an antibody fragment derived from the full PI3K p85 alpha antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL589 recognizes the human Phosphoinositide 3-kinase (PI3K), also known as phosphatidylinositol 3-kinase which belongs to the family of related intracellular signal transducer enzymes. PI3Ks are involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Mutations in the gene promote the development of diseases such as allergies, heart diseases, inflammatory processes or cancer. The superfamily of PI3 Kinases consists of several enzymes, which are structurally closely related.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Phosphatidylinositol 3-kinase, PI3-kinase, anti-PI3K p85 alpha, PIK3R1, GRB1

Detailed product information

Technical specifications

CloneREAL589
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenPI3K p85 α
Alternative names of antigenPhosphatidylinositol 3-kinase, PI3-kinase, anti-PI3K p85 alpha, PIK3R1, GRB1
Distribution of antigenubiquitous, tonsil
RRIDAB_2857715, AB_2857714

Resources for PI3K p85 α Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
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References for PI3K p85 α Antibody, anti-human, REAdye_lease™

Publications

  1. Thorpe, L. M. et al. (2015) PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat. Rev. Cancer 15(1): 7-24
  2. Kaneda, M. M. et al. (2016) PI3Kγ is a molecular switch that controls immune suppression. Nature 539(7629): 437-442
  3. Rodgers, S. J. et al. (2017) Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. Biosci. Rep. 37(1): BSR2016043

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