CpG ODNs are widely used for activation of immune cells or induction of signalling in TLR9-expressing recombinant cell lines.
Control compounds which contain GpC dinucleotides instead of CpGs are useful to control for the CpG specificity of this effects.

Specifications for ODN 2216 Control (ODN 2243)

Overview

CpG ODNs are widely used for activation of immune cells or induction of signalling in TLR9-expressing recombinant cell lines.
Control compounds which contain GpC dinucleotides instead of CpGs are useful to control for the CpG specificity of this effects.

Detailed product information

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells
1,2
. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs
3
.
Control compounds for CpG ODNs share the sequence with their stimulatory counterparts but contain GpC dinucleotides instead of the CpG motifs.

Applications

ODN 2216 Control (ODN 2243) can be used as a sequence control for A-class ODN 2216.

Resources for ODN 2216 Control (ODN 2243)

Documents and Protocols

References for ODN 2216 Control (ODN 2243)

Publications

  1. Hemmi, H. et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745
  2. Krieg, A. M. et al. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-549
  3. Bauer, S. et al. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U.S.A. 98: 9237-9242

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