Clone:
REA1219
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Notch 3

Specifications for Notch3 Antibody, anti-human, REAfinity™

Overview

Clone REA1219 recognizes the extracellular domain of human Notch3, one of four members of the Notch family of receptors. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members, the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multi-protein complex. Notch3 is expressed on various various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. It can also be expressed on vascular smooth muscle and cells of the central nervous system. In addition, the altered expression of Notch3 by various leukemias, lymphomas and cancers has been reported.
Additional information: Clone REA1219 displays negligible binding to Fc receptors.

Alternative names

Notch 3

Detailed product information

Technical specifications

CloneREA1219
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenNotch3
Alternative names of antigenNotch 3
Molecular mass of antigen [kDa]240
Distribution of antigenT cells, hematopoietic stem and progenitor cells, smooth muscle
Entrez Gene ID4854
RRIDAB_2811618, AB_2811624, AB_2811619, AB_2811625, AB_2811620, AB_2811626, AB_2811621, AB_2811627, AB_2811622, AB_2811623

Resources for Notch3 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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