Clone:
REA668
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
NACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin

Specifications for NLRP3 (NALP3) Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA668 recognizes the human and mouse NLRP3 antigen, also known as NACHT, LRR, and PYD domains–containing protein 3 (NALP3). NLRP3, a member of the NLR family of cytosolic receptors, is a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. NLRP3 plays a crucial role in innate immunity and inflammation and is a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. NLRP3 is mainly expressed in macrophages, but also expressed in dendritic cells, B cells, T cells, and osteoblasts.
Additional information: Clone REA668 displays negligible binding to Fc receptors.

Alternative names

NACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin

Detailed product information

Technical specifications

CloneREA668
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenNLRP3 (NALP3)
Alternative names of antigenNACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin
Molecular mass of antigen [kDa]118(same molecular weight for human and mouse/rat)
Distribution of antigenB cells, T cells
Entrez Gene ID114548, 216799
RRIDAB_2653035, AB_2653036, AB_2653037, AB_2653034

Resources for NLRP3 (NALP3) Antibody, anti-human/mouse, REAfinity™

Certificates

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References for NLRP3 (NALP3) Antibody, anti-human/mouse, REAfinity™

Publications

  1. McCall, S. H. et al. (2008) Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J. Bone Miner. Res. 23(1): 30-40
  2. Bae, J. Y. et al. (2011) Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly. J. Biol. Chem. 286(45): 39528-39536
  3. Haneklaus, M. et al. (2013) Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr. Opin. Immunol. 25(1): 40-45

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