CD8b antibodies, mouse

CD8b antibodies, mouse

Clone: REA793 | Dilution: 1:50
Clone REA793 recognizes both alloantigeneic forms of the mouse CD8b antigen, a single-pass type I membrane protein also known as lymphocyte antigen 3 (Ly-3 or Lyt-3). The CD8 molecule is composed of two distinct polypeptide chains that pair on the cell surface either as a CD8aa homodimer or as a CD8ab heterodimer. These forms of the CD8 molecule are differentially expressed on functionally distinct CD8
+
lymphocyte subsets. The CD8ab heterodimer is expressed on cytotoxic T cells and thymocytes.
Additional information: Clone REA793 displays negligible binding to Fc receptors.

Alternative names

Cd8b1, Ly-3, Ly-C, Lyt-3

Technical specifications

  • Antigen: CD8b
  • Clone: REA793
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Cd8b1, Ly-3, Ly-C, Lyt-3
  • Entrez Gene ID: 12526
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: T cells, lymphocytes, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Nakayama, K. et al. (1989) Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments. J. Immunol. 142(7): 2540-2546
    2. Blanc, D. et al. (1998) Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants. Eur. J. Immunol. 18(4): 613-619
    3. Chang, H. C. et al. (2005) Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity 23(6): 661-671
  • gentleMACS Protocols

Product options: 18
130-111-710

CD8b-FITC, mouse

30 µg in 200 µL (1)
EUR 45,00 
130-111-632

CD8b-FITC, mouse

150 µg in 1 mL (1)
EUR 130,00 
130-111-711

CD8b-PE, mouse

30 µg in 200 µL (1)
EUR 85,00 
130-111-633

CD8b-PE, mouse

150 µg in 1 mL (1)
EUR 245,00 
130-111-712

CD8b-APC, mouse

30 µg in 200 µL (1)
EUR 85,00 
130-111-634

CD8b-APC, mouse

150 µg in 1 mL (1)
EUR 245,00 
30 µg in 200 µL (1)
EUR 105,00 
150 µg in 1 mL (1)
EUR 300,00 
30 µg in 200 µL (1)
EUR 105,00 
150 µg in 1 mL (1)
EUR 300,00 
30 µg in 200 µL (1)
EUR 110,00 
150 µg in 1 mL (1)
EUR 320,00 
30 µg in 200 µL (1)
EUR 110,00 
150 µg in 1 mL (1)
EUR 320,00 
30 µg in 200 µL (1)
EUR 110,00 
150 µg in 1 mL (1)
EUR 320,00 
30 µg in 200 µL (1)
EUR 45,00 
150 µg in 1 mL (1)
EUR 130,00 

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