CD317 (BST2) antibodies, human

CD317 (BST2) antibodies, human

Clone: REA202 | Dilution: 1:11
Clone REA202 recognizes the CD317 antigen, which is a lipid raft-associated type II transmembrane glycoprotein. CD317 is composed of a short N-terminal cytosolic domain, a transmembrane domain, and a C-terminal glycosyl-phosphatidylinositol anchor. Expression of CD317 is upregulated in the presence of IFN-α on T and B cells, is found on the apical surface of polarized epithelial cells, and on myeloma cells. CD317 expression is also found in an intracellular pool and the protein cycles between this intracellular pool and the cell surface in a clathrin dependent manner. It has been shown to play a role in regulating the growth and development of B cells, cell adhesion, cell migration, and in cultured cells. CD317 restricts the release of formed viral particles at the surface of infected cells.
Additional information: Clone REA202 displays negligible binding to Fc receptors.

Alternative names

BST2, Tetherin, PDCA1, HM1.24

Technical specifications

  • Antigen: CD317 (BST2)
  • Clone: REA202
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: BST2, Tetherin, PDCA1, HM1.24
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    pigtail monkey (
    Macaca nemestrina
    )
  • Distribution of antigen: B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Habermann, A. et al. (2010) CD317/Tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection. J. Virol. 84: 4646-4658
    2. Rollason, R. et al. (2009) A CD317/tetherin–RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J. Cell Biol. 184: 721-736
Product options: 12
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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