CD255 (TWEAK) antibodies, human

CD255 (TWEAK) antibodies, human

Clone: CARL-1 | Dilution: 1:11
Clone CARL-1 reacts with the type II transmembrane protein CD255, also known as TWEAK, belonging to the TNF superfamily. It exists as membrane-bound and secreted form and is expressed on most tissues but not or weakly on hematopoietic lineage lines. TWEAK interacts with its receptor APO-3, which promotes inerleukin 8 (IL-8) secretion, activation of NF-κB, and endothelial cell proliferation and apoptosis.

Alternative names


Technical specifications

  • Antigen: CD255 (TWEAK)
  • Clone: CARL-1
  • Isotype: mouse IgG3κ
  • Alternative names of antigen: TNFSF12, APO3L, Dr3lg, TWEAK
  • Entrez Gene ID: 8742
  • Molecular mass of antigen [kDa]: 27
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin
  • Selected references

    1. Kaplan, M. J. et al. (2000)
      TRAIL (Apo2 Ligand) and TWEAK (Apo3 Ligand) mediate CD4
      T cell killing of antigen-presenting macrophages.
      J. Immunol. 164: 2897-2904
    2. Chicheportiche, Y. et al. (1997) TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 272: 32401-32410
    3. Lynch, C. N. et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J. Biol. Chem. 274: 8455-8459
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