CD205 (DEC205) antibodies, mouse

CD205 (DEC205) antibodies, mouse

Clone: NLDC-145 | Dilution: 1:10
The CD205 antibody recognizes a 205 kDa integral membrane glycoprotein also known as DEC205 (dendritic and epithelial cells, 205 kDa).
1,2
This membrane protein acts as an endocytic receptor and thereby mediates efficient processing and presentation of antigens
in vivo
, leading to the induction of T cell immunity or tolerance
3
. CD205 is expressed at high levels on mouse dendritic cells (DCs) in the skin (Langerhans cells), on DCs residing in the T cell areas of peripheral lymphoid organs, and on DCs generated
in vitro
from bone marrow progenitors.
4
To a much lower extent, CD205 is also expressed on mature B cells, granulocytes, and T cells.
1,2

Alternative names

LY75, DEC-205

Technical specifications

  • Antigen: CD205 (DEC205)
  • Clone: NLDC-145
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: LY75, DEC-205
  • Entrez Gene ID: 17076
  • Molecular mass of antigen [kDa]: 195
  • Distribution of antigen: dendritic cells, epithelial cells, Langerhans cells, lymphocytes, spleen, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Inaba, K. et al. (1995) Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes. Cell. Immunol. 163: 148-156
    2. Witmer-Pack, M. D. et al. (1995)
      Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression
      in situ
      in lymphoid and nonlymphoid tissues.
      Cell. Immunol. 163: 157-162
    3. Bonifaz, L. et al. (2002)
      Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8
      +
      T cell tolerance.
      J. Exp. Med. 196: 1627-1638
    4. Kraal, G. et al. (1986) Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163: 981-997
Product options: 6
9 µg in 300 µL (1)
EUR 40,00 
30 µg in 1 mL (1)
EUR 85,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 71,00 
30 µg in 1 mL (1)
EUR 110,00 
30 µg in 1 mL (1)
EUR 45,00 

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