CD125 (IL-5Rα) antibodies, human

CD125 (IL-5Rα) antibodies, human

Clone: REA705 | Dilution: 1:50
Clone REA705 recognizes the human CD125 (IL-5Rα) antigen, a subunit of the heterodimeric interleukin 5 (IL-5) receptor which binds to IL-5. The human IL-5 receptor has an a subunit (IL-5Rα) and a b subunit (βC) that are able to activate the Janus kinases JAK1 and JAK2 and a signal transducer and activator of transcription (STAT5). CD125 is expressed on eosinophils and basophils.
Additional information: Clone REA705 displays negligible binding to Fc receptors.

Alternative names

IL-5RA, CDw125

Technical specifications

  • Antigen: CD125 (IL-5Rα)
  • Clone: REA705
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL-5RA, CDw125
  • Entrez Gene ID: 3568
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: eosinophils, basophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
  • Selected references

    1. Blom, M. et al. (1994) Granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3. Blood 83(10): 2978-2984
    2. Ogata, N. et al. (1998) JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood 91(7): 2264-2271
Product options: 4
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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