CD106 (VCAM-1) antibodies, human

CD106 (VCAM-1) antibodies, human

Clone: REA269 | Dilution: 1:11
Clone REA269 recognizes the CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1) or INCAM-100. CD106 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
Additional information: Clone REA269 displays negligible binding to Fc receptors.

Alternative names

VCAM1, INCAM-100

Technical specifications

  • Antigen: CD106 (VCAM-1)
  • Clone: REA269
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: VCAM1, INCAM-100
  • Entrez Gene ID: 7412
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: endothelial cells, dendritic cells, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Osborn, L. et al. (1992) Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1. J. Exp. Med. 176(1): 99-107
    2. Johnson, L. A. et al. (2008) Cell traffic and the lymphatic endothelium. Ann. N. Y. Acad. Sci. 1131: 119-133
    3. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
Product options: 10
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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