Anti-LRP-4 antibodies, human

Anti-LRP-4 antibodies, human

Clone: REA552 | Dilution: 1:11
Clone REA552 recognizes the human LRP-4 antigen, a β-propeller containing protein, which is a member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. LRP-4 is expressed in bone and cultured osteoblasts and binds Dkk1 and sclerostin
in vitro
. It plays a physiological role in the regulation of bone growth and turnover.
Additional information: Clone REA552 displays negligible binding to Fc receptors.

Alternative names

Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816

Technical specifications

  • Antigen: LRP-4
  • Clone: REA552
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816
  • Entrez Gene ID: 4038
  • Molecular mass of antigen [kDa]: 210
  • Distribution of antigen: bone, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Choi, H. Y. et al. (2009)
      Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover
      in vivo
      .
      PLoS One 4(11): e7930
    2. Leupin, O. et al. (2011) Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J. Biol. Chem. 286(22): 19489-19500
    3. Holdsworth, G. et al. (2012) Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors. J. Biol. Chem. 287(32): 26464-26477
Product options: 6
for 30
tests
(1)
EUR 125,00 
for 100
tests
(1)
EUR 295,00 
for 30
tests
(1)
EUR 125,00 
for 100
tests
(1)
EUR 295,00 
for 30
tests
(1)
EUR 105,00 
for 100
tests
(1)
EUR 245,00 

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