Anti-KIR2D antibodies, human

Anti-KIR2D antibodies, human

Clone: REA1042 | Dilution: 1:50
Clone REA1042 recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).
Additional information: Clone REA1042 displays negligible binding to Fc receptors.

Alternative names

CD158A

Technical specifications

  • Antigen: KIR2D
  • Clone: REA1042
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD158A
  • Entrez Gene ID: 3806, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292, 100132285
  • Molecular mass of antigen [kDa]: 31-39
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
    2. Djeu, J. et al. (2002) A view to a kill: signals triggering cytotoxicity. Clin. Cancer Res. 8: 636-640
    3. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
Product options: 21
130-117-626

Anti-KIR2D-FITC, human

for 30
tests
(1)
EUR 105,00 
130-117-477

Anti-KIR2D-FITC, human

for 100
tests
(1)
EUR 245,00 
130-117-627

Anti-KIR2D-PE, human

for 30
tests
(1)
EUR 125,00 
130-117-478

Anti-KIR2D-PE, human

for 100
tests
(1)
EUR 295,00 
130-117-628

Anti-KIR2D-APC, human

for 30
tests
(1)
EUR 125,00 
130-117-479

Anti-KIR2D-APC, human

for 100
tests
(1)
EUR 295,00 
130-117-629

Anti-KIR2D-VioBlue, human

for 30
tests
(1)
EUR 125,00 
130-117-480

Anti-KIR2D-VioBlue, human

for 100
tests
(1)
EUR 300,00 
130-117-630

Anti-KIR2D-VioGreen, human

for 30
tests
(1)
EUR 125,00 
130-117-481

Anti-KIR2D-VioGreen, human

for 100
tests
(1)
EUR 300,00 
130-117-631

Anti-KIR2D-PE-Vio615, human

for 30
tests
(1)
EUR 130,00 
130-117-482

Anti-KIR2D-PE-Vio615, human

for 100
tests
(1)
EUR 310,00 
130-117-632

Anti-KIR2D-PE-Vio770, human

for 30
tests
(1)
EUR 130,00 
130-117-483

Anti-KIR2D-PE-Vio770, human

for 100
tests
(1)
EUR 310,00 
130-117-484

Anti-KIR2D-APC-Vio770, human

for 100
tests
(1)
EUR 310,00 
130-117-634

Anti-KIR2D-PerCP-Vio700, human

for 30
tests
(1)
EUR 130,00 
130-117-485

Anti-KIR2D-PerCP-Vio700, human

for 100
tests
(1)
EUR 310,00 
130-117-635

Anti-KIR2D-VioBright 515, human

for 30
tests
(1)
EUR 165,00 
130-117-486

Anti-KIR2D-VioBright 515, human

for 100
tests
(1)
EUR 390,00 
130-117-636

Anti-KIR2D-Biotin, human

for 30
tests
(1)
EUR 105,00 
130-117-487

Anti-KIR2D-Biotin, human

for 100
tests
(1)
EUR 245,00