Anti-IL-27 p28 antibodies, mouse

Anti-IL-27 p28 antibodies, mouse

Clone: REA371 | Dilution: 1:10
Clone REA371 recognizes the mouse IL-27 p28 antigen, a secreted molecule which binds Epstein-Barr virus-induced gene 3 (EBI3) to form the heterodimeric cytokine IL-27. IL-27 is expressed by antigen-presenting cells, including macrophages and dendritic cells, in the early phase after antigen-mediated activation. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells. In vivo, its most important role appears to be that of immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses in a range of infectious and noninfectious situations. These activities of IL-27 are dependent on simultaneous T cell receptor activation and occur in synergy with IL-12. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL-27 p28 is only poorly secreted without coexpression of EBI3.
Additional information: Clone REA371 displays negligible binding to Fc receptors.

Alternative names

Il30, p28, IL-27A

Technical specifications

  • Antigen: IL-27 p28
  • Clone: REA371
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Il30, p28, IL-27A
  • Entrez Gene ID: 246779
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Pflanz, S. et al. (2002)
      IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4
      +
      T cells.
      Immunity 16(6): 779-790
    2. Lucas, S. et al. (2003)
      IL-27 regulates IL-12 responsiveness of naive CD4
      +
      T cells through Stat1-dependent and -independent mechanisms.
      Proc. Natl. Acad. Sci. U.S.A. 100(25): 15047-15052
    3. Batten, M. et al. (2007) The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85(7): 661-672
Product options: 6
9 µg in 300 µL (1)
EUR 40,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 58,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 71,00 
30 µg in 1 mL (1)
EUR 110,00 

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