Anti-DLL4 antibodies, mouse

Anti-DLL4 antibodies, mouse

Clone: HMD4-1 | Dilution: 1:10
DLL4 is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, Delta/Serrate/LAG-2 (DSL) domain and tandemly arranged multiple EGF like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. A ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling.

Alternative names


Technical specifications

  • Antigen: DLL4
  • Clone: HMD4-1
  • Isotype: hamster IgG
  • Alternative names of antigen: Delta4
  • Entrez Gene ID: 54485
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: endothelial cells, heart
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Duarte, A. et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18: 2474-2478
    2. Krebs, L. T. et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469-2473
    3. D'Souza, B. et al. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol. 92: 73-129
Product options: 6
9 µg in 300 µL (1)
EUR 40,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 60,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 20,00 
30 µg in 1 mL (1)
EUR 45,00