Anti-Aiolos antibodies, mouse

Anti-Aiolos antibodies, mouse

Clone: REA655 | Dilution: 1:10
Clone REA655 recognizes the mouse Aiolos antigen, a member of the Ikaros family of zinc finger transcription factors, also known as IKZF3. The expression is restricted to lymphoid tissues. Aiolos is highly expressed in spleen and mature B cells and at lower levels in thymus and bone marrow. It was first detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre–T and pre–B cell precursors. It is suggested, that the increase of Ikaros and Aiolos in differentiating lymphocytes is essential for normal progression to a mature and immunocompetent state. Aiolos interacts with Ikaros to regulate lymphocyte differentiation.
Additional information: Clone REA655 displays negligible binding to Fc receptors.

Alternative names

IKZF3, Zfpn1a3, Znfn1a3, 5830411O07Rik

Technical specifications

  • Antigen: Aiolos
  • Clone: REA655
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IKZF3, Zfpn1a3, Znfn1a3, 5830411O07Rik
  • Entrez Gene ID: 22780
  • Molecular mass of antigen [kDa]: 58
  • Distribution of antigen: spleen, B cells, thymocytes, bone marrow
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Morgan, B. et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16(8): 2004-2013
    2. Wang, J. H. et al. (1998) Aiolos regulates B cell activation and maturation to effector state. Immunity 9(4): 543-553
    3. Huttlin, E. L. et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143(7): 1174-1189
Product options: 4
9 µg in 300 µL (1)
EUR 40,00 
30 µg in 1 mL (1)
EUR 85,00 
9 µg in 300 µL (1)
EUR 58,00 
30 µg in 1 mL (1)
EUR 85,00 

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