Human PDGF-BB IS

Human PDGF-BB IS

PDGF-BB IS stands for platelet derived growth factor BB "Improved Sequence". Human PDGF-BB IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. Human PDGF-BB IS possesses the same properties as naturally occurring PDFG-BB.

Applications

Human PDGF-BB IS can be used for a variety of applications, including:
  • MSC culture and investigation of MSC development.
  • Studies of angiogenesis.

Background information

Platelet-derived growth factor-BB (PDGF-BB) is a dimeric protein composed by two identical B subunits, it belongs to the PDGF family together with the two receptors PDGFRα and PDGFRβ. PDGF-BB binds PDGFRβ with the highest affinity. It regulates mesenchymal cell growth, morphogenesis, and migration, especially during angiogenesis and glial cell proliferation. A dysregulation of PDGF was shown in diseases such as diabetes, and in deficit of bone formation and reparation. Human PDGF-BB IS is an engineered PDGF-BB variant retaining the same biological properties as natural accurring PDGF-BB.

Biological activity

  • Proliferation of 3T3 cells (NIBSC 94/728)
  • premium grade: ≥ 1×
    10
    6
    IU/mg
  • research grade: ≥ 5×
    10
    5
    IU/mg
  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 6
Pichia pastoris
10 µg
EUR 135,00 
Pichia pastoris
25 µg
EUR 210,00 
Pichia pastoris
10 µg
EUR 165,00 
Pichia pastoris
25 µg
EUR 265,00 
Pichia pastoris
100 µg
EUR 525,00 
Pichia pastoris
1000 µg
EUR 2 220,00