Clone:
REA1043
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Ly-49 inhibitory receptor I

Specifications for Ly-49I Antibody, anti-mouse, REAfinity™

Overview

Clone REA1043 recognizes the mouse Ly49I antigen, a single-pass type II C-type lectin-like membrane glycoprotein also known as Ly49 inhibitory receptor I. The Ly49 receptors are encoded by a family of highly polymorphic and polygenic genes within the mouse NK gene complex which includes genes that encode both inhibitory and activating Ly49 receptors. Ly49 receptors recognize MHC-I and MHC-I–like proteins on normal as well as on altered cells. They are described as being expressed on both the developing and mature NK cells. The inhibitory Ly49 receptors are involved in NK cell education, a process in which NK cells acquire function and tolerance toward cells that express “self-MHC-I.” On the other hand, the activating Ly49 receptors recognize altered cells expressing activating ligands. Ly49 receptors have been described on multiple NK cell subsets, such as uterine NK and memory NK cells, as well as NKT cells, dendritic cells, plasmacytoid dendritic cells, macrophages, neutrophils, and cells of the adaptive immune system, such as activated T cells and regulatory CD8
+
T cells. Ly49I is an inhibitory receptor capable of down-modulating proliferation, IFN-γ response, and cytotoxic activity in cells that express it.
Additional information: Clone REA1043 displays negligible binding to Fc receptors.

Alternative names

Ly-49 inhibitory receptor I

Detailed product information

Technical specifications

CloneREA1043
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49I
Alternative names of antigenLy-49 inhibitory receptor I
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells
Entrez Gene ID16640
RRIDAB_2733604, AB_2733741, AB_2733742, AB_2733321, AB_2733322, AB_2732946, AB_2732947, AB_2733190, AB_2733191, AB_2733088, AB_2733486, AB_2733487, AB_2733603

Resources for Ly-49I Antibody, anti-mouse, REAfinity™

Certificates

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to search for Certificates of Analysis (CoA) by lot number.

References for Ly-49I Antibody, anti-mouse, REAfinity™

Publications

  1. Wong, S. et al. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147(4): 1417-1423
  2. Dimasi, N. et al. (2002) Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family. J. Mol. Biol. 320(3): 573-585
  3. Tu, M. M. et al. (2014) Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 74(14): 3684-3694

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