Clone:
HBF-719
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Specifications for Ly-49F Antibody, anti-mouse

Overview

Clone HBF-719 recognizes the mouse killer cell lectin-like receptor 6 (Ly-49F) antigen, a type II transmembrane natural killer cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. The inhibitory receptor Ly-49F is expressed on subsets of NK cells, NK-T cells, and on a subpopulation of memory T cells in C57BL/6 mice, but not AKR/J, BALB/c, C3H/HeN, DBA/1, or SJL mice. IL-21 selectively down-regulates Ly-49F on mature NK cells.

Alternative names

Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Detailed product information

Technical specifications

CloneHBF-719
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Speciesmouse
AntigenLy-49F
Alternative names of antigenKlra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, NKT cells
Entrez Gene ID16637
RRIDAB_2652742, AB_2652743, AB_2652744, AB_2652745, AB_2652746, AB_2652747, AB_2652748, AB_2652749, AB_2652750, AB_2652751, AB_2652752, AB_2652741

Resources for Ly-49F Antibody, anti-mouse

Certificates

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References for Ly-49F Antibody, anti-mouse

Publications

  1. Gays, F. et al. (2005) Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J. Immunol. 175(5): 2938-2947
  2. Smith, H. R. et al. (1994) Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol. 153(3): 1068-1079
  3. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77

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Ly-49F Antibody, anti-mouse

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