Clone:
REA253
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klra3, Klra9

Specifications for Ly-49C/I Antibody, anti-mouse, REAfinity™

Overview

Clone REA253 recognizes the mouse lymphocyte antigen 49c (Ly-49C), a type II transmembrane protein which is also known as killer cell lectin-like receptor 3 (Klra3). The REA253 antibody reacts with Ly-49C of BALB, B6, NZB, C57BL, and Ly-49I of B6 mice strains. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49C is a cell surface molecule expressed on a subpopulation of murine natural killer cells and NK1.1 T cells that are involved in the specific rejection of H-2
d
or H-2
f
(hemopoietic histocompatibility determinant 2) bone marrow cell grafts. It transduces a negative signal to NK cells upon recognition of class I antigens. The particular allele of Ly-49C, i.e., C57BL versus BALB, determines to a large extent which class I antigen (H-2K
b
for B6, K
b
and H-2
d
for BALB/c or BALB.B) sends negative signals to Ly-49C
+
NK cells. Clone REA253 blocks the binding of Ly-49C to MHC class I antigens of the b, d, k, and s haplotypes. The epitope recognized by REA253 may be masked on NK cells due to interactions with MHC class I molecules.
Additional information: Clone REA253 displays negligible binding to Fc receptors.

Alternative names

Klra3, Klra9

Detailed product information

Technical specifications

CloneREA253
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49C/I
Alternative names of antigenKlra3, Klra9
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells
Entrez Gene ID16634, 16640
RRIDAB_2652704, AB_2652705, AB_2652706, AB_2652707, AB_2652708, AB_2652703

Resources for Ly-49C/I Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Ly-49C/I Antibody, anti-mouse, REAfinity™

Publications

  1. Yu, Y. Y. et al. (1996) The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 4(1): 67-76
  2. Brennan, J. et al. (1996) Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J. Exp. Med. 184(6): 2085-2090
  3. Stoneman, E. R. et al. (1995) Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J. Exp. Med. 182(2): 305-313

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