Clone:
NKVFS1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
CD158A

Specifications for KIR2D Antibody, anti-human

Overview

The Anti-KIR2D antibody recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell-mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).

Alternative names

CD158A

Detailed product information

Technical specifications

CloneNKVFS1
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenKIR2D
Alternative names of antigenCD158A
Molecular mass of antigen [kDa]31-39
Distribution of antigenNK cells, T cells
Entrez Gene ID3806, 100132285, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292
RRIDAB_2819517, AB_2660017, AB_2660018, AB_2660020, AB_871568, AB_2660021, AB_2660022, AB_2660023, AB_2660024, AB_2660025, AB_871569, AB_871567, AB_2819552

Resources for KIR2D Antibody, anti-human

Documents and Protocols

App notes/customer reports

Cross-reactivity of KIR antibodies

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for KIR2D Antibody, anti-human

Publications

  1. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
  2. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196

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